Tooth extraction in patients treated with bisphosphonates (BPs) for osteoporosis or cancer\nexposes the patient to the risk of osteonecrosis of the jaw. An autologous membrane using platelet-rich\nfibrin (PRF) is an innovative technique to promote wound healing, which allows obtaining a hermetic\nclosure of the post-extractive surgical site without the need of mucoperiosteal flaps or periosteal\nreleasing incisions. Here, we report the case of a 70-year-old woman, in therapy with alendronate\nfor 12 years, requiring the upper right premolar extraction because of a crown fracture. After the\ntooth extraction performed under antiseptic and antibiotic coverage, the PRF autologous membrane\nwas placed on the surgical wound to close completely the post-extraction site. Follow-up visits\nwere carried out after one, two, four weeks and two months from the intervention. The complete\nre-epithelization of the wound was observed without signs of infection. The use of PRF for the closure\nof post-extraction sockets in patients taking BPs appears to be a promising alternative to the more\ninvasive surgical procedures. Future clinical trials will be pivotal in elucidating the effectiveness of\nPRF to prevent BP-related osteonecrosis after tooth extraction.
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